Unless you way WAY overheat your barrel you aren't going to get to a point where strength of the correct thread locker is impacted by firing schedule. Just don't try to unscrew a suppressor on a brake when it when it's hot because generally the can will be locked on the brake tighter than then brake on the barrel and at the end of the day there's only so much break away torque any thread locker can add. Metal expands when it's hot, and the difference in expansion between titanium, aluminum, and steel comes in to play on the can whereas the brake and barrel are both steel.
Loctite 272 only looses about 25% of it's strength up to 200*C (392*f), book says heat to 250*C (482*f) to remove. If you're shooting a barrel hotter than 50-60*C then you're at the mercy of however much powder you have in the case in terms of what is happening to your throat.
I'm not going to beat up on a precision barrel like that, I'm really not sure I even could unless I decided to use my 300 RUM for a 12-shot 2-minute PRS stage
The above is limited to bolt action rifles, any gentlemen who run ARs like FPS arcade game characters might need to invest in pinned muzzle devices. I don't have problems with my 300 BLK but I'm low-speed high-drag in that world.