It's eerily calm this morning. So...
Unless the liver isn't considered a vital organ, the center of the vital zone on a broadside large game animal will be located behind its front leg bone.
If you hit forward of the front leg bone on a broadside animal at long range, after bullet velocity has slowed, good luck. Because that's what you'll need to recover that animal.
On the original subject which started this Thread... Targeting the spine at long range never enters my mind. At closer ranges, more options become possible due to the improved ability to actually hit the aim point. At long range, my aim point builds in the most forgiveness for bullet drift in any and every direction. Which necessitates a crosshair hold behind the front leg bone, mid-height in body.
I aim just clear of the shoulder meat. No problems.
For those that believe this hit location lacks lethality, you'd have to also conclude that archers never target a lethal/vital organ aim point on the animals they kill.