I know guys are killing them with .22 CFs but I think I'd stay with a 6mm or 6.5 of some variety. I've had great success on mule deer with a 6mm Rem. Bullet design and construction has definitely upped the game for smaller, HV calibers.
My two grandsons and I kill N. Missouri Whitetails with: 7mm08, 243 Win, .35 Rem, and 7RM. I have a new 7 RSAUM which didn't draw blood in 2023, but; only because their .243 Win and 7mm08 killed on first shot and two were enough! My oldest grandson has killed a Deer every year for 8 years straight with a Colt Sauer .243 Win. Our shots are from blinds or elevated stands with range of 75 to 275 yards. We have suffice WT population we wait for shots less than 300 yds. FYI, our N. Missouri WT give Mulies a run for their money. Lastly, agree with 50 driver, be nice and respect other's opinions.A .243 AI will be perfect. .260 Rem AI is also a favorite.