I did this past November. After about 17 years, I finally drew an Az Strip Mule Deer tag. I dusted off my 358 Norma and worked up a load shooting Hammers that grouped an honest half MOA. Put a nice new Vortex Viper HST on it. Teated the knobs up and down, left and right, and it was rock solid over and over. Practiced at the house out to 500 yds with very predictable results (when I did my part). After 5 days of scouting and 5 days of serious hunting, and passing on several smaller bucks, my brother spots the one. Beautiful big ol strip buck, north of 190". I ranged him at 375 straight p the side of a steep mountain. I flop down on my arce, rest my rifle on my tripod, and dial up. Boom, brother says high and to the right. Duh I dial back to 350 for the incline and- missed to the right. I look at the windage knob and its not on zero. Dammit. I rolled it back to the zero and-missed #3. I grabbed the scope and tried to wiggle it. Something come loose? Cant feel it. Brother is getting worse but i settled down. Ol Buck just walking back and forth a few steps with every shot, but not running off. Took a breath and set right on his shoulder, boom. Told my brother "got him". He said nope, you missed. No, I didn't friggin miss that one. Ya, you missed. Boom send #5 Got him! No, brother you missed again. Buck finally trots off out of sight, and I hike my befuddled *** up there looking for blood. Not a drop, and it's getting dark. Hunt the next morning with my spare gun but cant find him, then I take it up the road where I had some room, and it's 9" or so right at 50 yds. I had to back up the windage another two full turns, then nuts on zero once again. Don't know what I did to move the knob, either being lashed on my backpack, or going in and out of the scabbard on my buggy is all i can figure. I used on of them scope condoms that I thought would protect those exposed turrets, but I was obviously overconfident. Back at camp I applied the appropriate amount of gorilla tape on that side knob. No blame from me on Vortex, I love the scope, but I missed the buck of a lifetime. Hunted 4 more days but never fount another shooter.
Locking turrets or tape your knobs my friends.