I have owned many 22-250's and as tigguy points out, there are numerous great powders for the caliber. What works well in one gun, may not do so in another. Notice that most of these are in the medium burn range. You need to find a good reloading manual and use it as a guide.
My newest is a factory Rem 700 VS, and I have tried many good bullets and powders, but it is a contemptable gun and 5 shot groups at 100 yds. were consistently above 1". My best load so far is 40.0 grains of AA2700 and the 53 gr. Sierra MK, with CCI 200 primer. Groups now average about 3/4" and I think that is about as well as it will do. Exchanging the factory barrel for a custom would certainly help.