Elk at ~280 and mule deer at 380 iirc last fall. If you look at the ballistic #'s and KE at 300-400 vs 500-600 the elk or deer isn't going to know any difference. : ) My Cow blew bone bits and blood all over the field behind her. The Mulie didn't move more than 0-3' due to extensive vertebrate damage although I hit him midrib.
With deer I am confident of ethical kill to 800 yards although the kinetic energy at 3200 yards would be good for another 400 yards - I find that 600-800 yard window very comfortable and TOF and wind band issues are not as big a deal in new terrain as a 1200 yard shot where the KE may still be good but other variables are indeterminable.
I used to shoot deer with a 0.313 G7 140 gr @ 3111 fps to 600-800 yards with no issues and now I run 0.340 G7 @ 3215 fps with more energy retention downrange albeit 9 grains lighter.
Coldbore and others have taken elk to 600-800 yards. For me personally, if an elk is at range, I will send one through the vitals and reload immediately to send a skeletal shoulder shot if the animal doesn't know what happened (most don't know what hit them at 600-800 yards, especially suppressed). Elk that find an arroyo whether its 6' or 50' deep make for a long day. If the animal's stance allowed for skeletal-to-vitals at 600-800 I would take that as a primary shot and be ready for a follow up.
I do the same with 284 Win, 7 Mag and 300 Win Mag too.