.416-.375 RUM is what I would build on the Rem 700 action. Medium or heavy palma contour and at least 27" of pipe. My 27" 3-groove pac-nor spits 340 grain cutting edge bullets at 3000 fps and is my go to long range load. The b.c. on them is .780 and they hold .25 MOA out to 1000 yards if I do my part.
Reuben
What kind of on game (terminal) performance are you getting with those projectiles, especially at longer ranges where the velocity has dropped?
And Tyler: the title says big rifles, are you trying to bring out the big guns? Lol