For the handloader with cast lead, jacketed and solid projectiles to choose from, not relying on manufactured ammo.
From distances of 25-50 yards to say 400.
If you could only choose one rifle (chambering) for an all-around hunter (moose, elk, black/brown bear, deer and hogs), what would you choose?
This is a subject for debate that has gone on for decades…if not centuries.
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Having a limited budget, before I bought my first high power rifle, I read everything I could on "Best All-Round Rifles" and "Most Versatile Chamberings" and was led (by numerous sources) to the 375 H&H Magnum.
I saved my shekels and purchased a Ruger #1 Tropical Rifle chambered in 375 H&H (which is still one of the most accurate rifles in my safe).
Yep, I played with any and every projectile and powder combination out there including FFFg black powder under the Sierra 300 grain spitzer boat tail!
Almost everything I tried was MOA or better but the absolute most accurate load I found was that same 300 grain bullet over a slightly compressed load of IMR4350.
Now, almost 40 years later, that load is all that gets used. It has been used on snakes, rabbits, crows, deer, tin cans, clay pigeons (resting on a dirt bank) and everything else I've had opportunity to hunt or shoot at! Were I to pursue Moose or Bears, I would try some Partitions or maybe monolithic solids instead of my beloved Boat Tail.
I suggest you consider realistically what you will be shooting at most often and select a caliber with efficient (balletically speaking), low cost projectiles that are easily had. Those beautiful 300 grain Sierras are easy to come by, but they don't come cheap in a box of 50!
Good luck and remember to have fun!