I'm pretty sure the 475 Turnbull is the most powerful lever action round at 4200#lb. The 50 Alaskan seems to come next at 4100#lb.
Of course if you load other rounds beyond specs and individual may exceed those numbers. If you are at my range testing them please let me know so I can go to the other side of the brick wall.
I have two or several 45-70 Govt. One is a Winchester model 1886 built in 1888. Immensely strong action. Loads can be made that become extremely uncomfortable to shoot except from a standing position.
I don't know much about the 50 Alaskan or the 475 Turnbull, but was impressed with the 45/70, So I decided to look at the "Factory" loadings and this is what I found. This may not be all the loads you can buy from the factory, but it should be close. these were the highest muzzle energy's I was able to find.
444 = Muzzle energy 3180 ft/lbs
45/70 = (In modern rifles) Muzzle energy 3309 ft/lbs.
450 Marlin = muzzle energy 3572 ft/lbs
460 S&W = (fired in a 26"barreled rifle) Muzzle energy 3861 ft/lbs.
500 S&W = Could not find any data for loads fired in a rifle, but when both the 460 and 500 were fired in pistols with the same barrel lengths they were very close (10 to 15 ft/lbs because of the higher velocity of the 460).
50 Alaskan = 4406 ft/lbs of muzzle energy.
I couldn't find any of the other cartridges mentioned that factory ammo was available in so that's where my search ended.
Note: these are all very powerful cartridges and should be fired in modern rifles. there are lots of 45/70s that cant handle these loads and should be limited to the loads that will produce 1600 ft/lbs
of muzzle energy.
They are all good performers and will do everything ask of them within reason.
The figures above should give a good representation of there power and use. And availability, price of ammo and rifles will most likely determine which one is best for the shooter.
So to answer the OPs question, There is no good answer because of usability, rifle weight, velocity/trajectory, recoil, ammo cost and availability, bullet selection, ETC. The most powerful may not be the best performer.
J E CUSTOM