I've been using 22-250 for 40 years. Shot too many to count. Lighter bullets are not reliable either close or far in this caliber in my experience. The trajectory is not the focus, but rather the bullet performance at distance and 55's perform better the farther you go out. In my experience polymers are problematic..sometimes they work and sometimes they dont. I have found a Sierra 52hpbt or Sierra 55 Spitzer to be deadly to 500 on coyote. Farther I would give nod to 55 Spitzer. Old style soft point bullets are still the best and I have tried them all. I tried lighter years ago and results were very poor. I've shot hundreds with 55 Sierra Spitzer and 36.5 of 4064 for 3650fps. Not many got away and I've shot a herd of them running, sitting, standing, scratching and every other situation. I would focus on performance vs speed.