So if you took 2000 yards out of the equation?
Seeing as that would be just for fun and I don't plan on trying to win the king of 2 miles competition any time soon. Would that sway you more towards 338. I think the cost per shot is going to be a minimal difference but the 375 will be more mainly due to the cost of the mono bullets, and burning 30 or so more grains of powder. Since the 338 still packs 2800 (give or take some) ft/lbs of energy at 1000 yards and chances are the 375 is going to have considerable more recoil and energy but does that really matter?