Riley,
I don't know how often you shoot game animals at really long range. If you often do, then you know the challenges with ranging, doping wind, etc.
The key is to practice with the rifle and ammo and at the distances (preferably beyond) where you'll be hunting so that you learn and know your own limitations. Then, run the numbers to see if you believe the terminal ballistics will support you.
So, pick your favorite Barnes bullets and the cartridge of your choice and go practice and determine your own limits. Once you do that, all of the opinions and marketing hype take a back seat.
I've hunted with a lot of bullets/conditions and good shot placement usually has a happy ending and poor placement leads to frustration.
As to your OP, 6.5x284 is a very competent cartridge. I've never run anything other than SMK and Bergers in several of mine. With short barrel life, I'm not likely to experiement with others. But, I'm sure it'll shoot Barnes, Nosler, or any other bullet as well as any 6.5mm cartridge. Unless you want more recoil with a 264WM or less recoil with 260 Rem.
Let us know what you decide and how that works out.
-- richard