With a .300 Win Mag, if you are sighted dead on at 200 yards you will be about 1.5" high at 100, 6" low at 300, and 18" low at 400 yards. That knowledge has allowed many hunters shoot game past 300 yards without adjusting their turrets.
If you are going with the Leupold 4.5-14x50, their B&C reticle will have hold points for 300, 400 with drop & windage plus elevation only at 450 & 500 yards. Although these may be off slightly, they will get you close enough for big game. If you go online you can fine-tune these to know what yardage they will be exact. Then, if you have time to adjust turrets, or the yardage is greater, you can still twist turrets. This gives you a FAST scope that is still accurate at ranges beyond which most of us should not be shooting.
Good luck & enjoy!