Here is my favorite .22-.250:
The stock is black walnut that I completely inletted from a shaped, un-inletted, Rem 700 blank to fit the Ruger M77 MKII - 8-10 coats of Minwax Wipe-On poly were applied, each coat sanded with 320 grit. The fore-end was made from 3, 3/4 inch thick epoxy laminated pieces of cherry salvaged from my late parent's bed-room furniture (I have lots of it). The cherry and walnut have complementary colors, with red under tones. The stock needed a moderate amount of shaping using a large cabinet file and finished with my Dewalt orbital sander to tune up edges & get nice flat surfaces. The rifle is about 16 years old & the stock is 14 years old and I just completely detailed the rifle & refinished the stock and glued on the forend tip.
I never did like the Ruger M77 diagonal bedding system so I drilled & tapped a 1/4 28 hole in the middle of the flat behind the funny Ruger M77 recoil lug. A standard Rem 700 1/4 28 Allen head front action screw was shortened. Two Allen head Ruger screws are used. I made this into a single shot and lowered the rifle profile about 3/16 inch. An aluminum Score High follower was J-B epoxy welded in place (it has been in place for 14 years). The gap in front of the aluminum follower was plugged up using Brownell's epoxy, to prevent glop from solvents and whatever from draining into stock.
It can be noted that this rifle is of the push feed type. The entire cartridge end is encircled by the bolt except for the ejector cut. This works well for a push feed/single shot. A Timney trigger was fitted.
The scope is a Leupold 6-18X40 AR Tac. The rifle also uses a 4.5-14X40 30mm VX3i. I don't like huge scopes. The 6-18 Leupold is of the Mil Rad type with mildots and mil adjustments and has been completely satisfactory.
A standard & proven load is the 75 Hornady ELDM with 34.5 grains of RL16. I also intend to work up a StaBall load with the same bullet. Longest hit so far on some hapless rodent was real close to 880 yards. The Hornady 4DOF calculator was very close. The barrel is a 26", 5R, 7.7 twist.
Wifey is also a .22-250 fan but likes 40 Vmax bullet over 4,000 fps but in a different rifle.
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