@Jon Bischof , I guess I don't have quite as pessimistic a view of the peer review process as you. Yes, there are problems, but I don't see them as pervasive as it appears you have experienced in your field. I do feel your pain as I have had poor reviews of my articles in that the responses led me to believe that a particular reviewer was not qualified to review my paper (this happens frequently in genomics where a journal editor may give a more statistically oriented paper to a bench/molecular scientist to review). Sometimes, you can ask for another reviewer to be used if you can rationally explain why. Peer review will never be perfect since as
@GunHawk pointed out, we scientists are just people.
An aspect of science that is often lost is that we fail all the time, and there is a bias toward not publishing those failures. When I set up an experiment to test something that I think is a real phenomena, I have to be willing to accept a few things. The first is that the data may tell me my idea is wrong, and I have to be ready to accept that outcome. The second is that while I have done everything I can think of to control outside influences on my data so that I can hone in on just the factor I'm interested in, there may be something I forgot or didn't know about that an external reviewer will pick up on. It happens, but happens less as I gain more experience and colleagues I can have review my plans before I implement them.
Now, back to our original question. We may never really know true answer to the question of the safety of lead bullets (or even copper if we were to try that experiment). The reasons are many. First, we do know that the impact of lead exposure is cumulative and happens over long periods of time. This means experiments are expensive since we have to not only design our experiment, but monitor it over some longer period of time than a single time point. We also cannot conduct this experiment in people. All research involving mammalian organisms is approved by a Institutional Review Board (IRB) of some type. The purpose of this board is to review the ethics (I hope Len will permit this use as this is the intention of this type of board and within the purview of their expertise) of any experiment involving mammals. They will not allow this to be performed on people, so we have to resort to a surrogate organism. Mice are a poor facsimile to people, rats are better, but probably pigs are best when it comes to modeling human nutrition. So, using pigs will be costly (we need a facility, we'll need to have enough pigs to sacrifice a few at every time point we monitor, and we need trained caretakers who will dutifully follow the research protocol). A board will still have to review this study before it can be conducted. We'll have to define meaningful endpoints to monitor (amount of lead accrued in tissues such as kidneys, liver, blood, brain, etc., and a way to monitor them (what assays do I use). All of those things cost money. Now, we want to simulate eating hunted game using frangible bullets. Do we use one specific bullet, or do we use a range within a class of frangible bullets? How do we simulate eating hunted game? Do we shoot goat carcasses? That will not be exactly the same as there is no active vasculature in a goat carcass, so maybe shoot live goats? Now, we're back to that IRB for approval again. How much goat meat, from how far out from the wound, and how often do we feed the pigs? Does the way we store the meat, or how the meat was processed (ground versus whole) matter?
As
@FEENIX pointed out earlier, no single experiment will answer all of those questions, so we're probably looking at several experiments, to answer all of those questions. A task like this would be well beyond the budget of most of the agencies who would care about such research. A partnership between wildlife organizations and the USDA might work, but would you rather fund this or habitat restoration?
So where does that leave us? We're unlikely to get the research done to truly answer the question the OP posted. We have a fair amount of empirical evidence that consuming game shot with frangible lead bullets is not highly lethal (people do not die in a detectably shorter time frame from non game eaters), although the other effects of lead consumption may be present (remember, the effects are cumulative over a long period of time which makes them hard to detect). Given all that, the safest route would be if you use a frangible lead bullet to dispatch your game, trim away the wound area and do not consume that trimmed meat. Eat away at the rest. Maybe one day we'll be able to do these studies and we'll get some good guidelines such as trim 5-6" out from the wound to be safe. We'll never know that information until we do the research.
And, that is why we do science. Not necessarily to prove a hypothesis or set out agenda, but to understand the facts as determined by the data we observe.