OP, I have a Hood Scope Checker mount.
It allows you to mount your scope along side a known good scope. You adjust both scopes to be pointing at the same spot on the target.
When you fire the rifle, you can see if both scopes are still POA. I have seen scopes shift when dry fired. If you can't find someone with one, I will be happy to loan you mine. Or just put a different scope it.
"Added note" The Hood Scope Checker uses Davidson style rings and bases. So you would need to put a Davidson style base on you rifle. If you would like to see what it looks like, I will be happy to post a picture of the set up tonight. Let me know.
Leupold manufactures great products, but they are not flawless.
With what you have described, that would be the first thing I would check.
I learned my lesson years ago with a Leupold BR 36X scope on a BR rifle that would shoot into the .1s (when I did my part). When I installed the scope, the rifle went to ****, could barely shoot a .250" group. Started chasing trying find out what happened. Changed bullets, loads, new brass. I was close to pulling the barrel when friend asked when the problem started, told him right after I mounted the Leup.
He asked me if I thought it could be the scope, "No way, its a Leupold!"
Told me to put the old scope back on, go back to my standard load and see what happens.
Put the Weaver 36X back on, first group was .135" group, I saved the target.
Since then, never take it for granted about anything. Look at all possibilites
Bottom line, just because it is a NEW Leupold, don't discount it out of the equation!
JMHO