I'm hearing what all the guys are saying, kinda all the same but different. All depends on what you wanna shoot at. Are you gonna go to the range and shoot all day or are you wanting to shoot an elk at 1000 yards. That's the question. Depending on which, the answer will be different. Myself I'm wanting to kill an elk at 1000 yards. That means one more variable... Kinetic energy. Velocity, BC and bullet weight all make up the kinetic energy. Basically a heavy bullet fast that flies good = lots of ft lbs. I shoot a 338-378 with a 300 grain nosler bullet with 107 grains of IMR 8133. Heavy fast and flies good through the air. BUT... if you wanna set on the range all day plinking steel then there's no need for kinetic energy, which in turn means you won't have the recoil from the heavy bullet with a heavy powder charge.