Most of these responses make me want to yawn. All towards the heavy bullets. Rainbow trajectory's. You didn't mention what you plan on killing? If your interested in "Wildcats", set up for killing Predators as for a calling rifle, speed kills, Light fast bullets. My favorite's are my "224 Vais"- 50 grain Nosler Ballistic tip at 4350 fps... Also my 20-250 with 40 grain bullets at 4300 fps and my 22 Middlestead. These three most always go with me on multi day predator hunts. Don't get caught up in all the hype about burning up the barrels with these hot rods. I've got at least a 1000 rounds in each of them and still have plenty of throat left. Probably due to the fact I usually shot once or twice at a time, never getting them hot. Now, if you were to use these on a high volume shoot like prairie dogs, squirrels etc. you'd toast those barrel's really quick, not worth it. There's the over the counter calibers like the 22-250 and 204 and 220 Swift and 223 , just to mention a few. Lapua brass available except for the swift? Most of my stuff is Lapua, it's like jewelry.