I've had the best accuracy in my 8 3/8" SW 629 DX and 4 5/8" SBH with max loads of H110/W296 (literally the same powder) and Hornady XTPs. From a steady rest, both pistols will print right around an inch at 25 yds. The Smith will send a 180 XTP at ~1900 fps and the 240 XTP at ~1450 fps. The Ruger will send them at 1750 and 1350 respectively. I don't think I'd use the 180 XTP for hunting, but it's about the best medicine I've seen for milk jugs and fruit. I've caught dozens of magnum bullets in water and wetpack, and the 240 XTP is a real beast. Good frontal expansion makes fist sized cavities 3-4" into wetpack, but there's the big shank left to drive them 16-20" deep. They don't go as deep as hard cast WFN bullets, but I'm pretty sure they'll pass through anything but the biggest critters (grizzly, buffalo, etc). Going much above a 240 in the 44 mag will really start eating up case volume, so I find them to be the best compromise of weight and speed.
The Speer Deep Curl also has textbook performance in wet pack, but I've never been able to get them to shoot as good as the XTP.
Regarding shooting skills, as mentioned, get lots of practice with what you hunt with. POI shift with different bullets can be SUBSTANTIAL in handguns. The two aforementioned XTPs print several inches different, even at 15 yds, which turns into
feet at 75-100 yds. The lighter bullets actually print
lower, which I believe is because they exit the barrel sooner during the muzzle rise under recoil.
I recently installed a Vortex Venom on my 454 Casull, and have another to put on the SW 629. The aiming precision and speed is outstanding, but finding the dot on presentation can be a bit difficult, so you'll want to practice a lot to get the muscle memory ingrained (dry fire in your man cave is great). Optics on revolvers sit way above irons, and if you're used to irons, you'll find yourself coming in low as you bring the pistol up, then hunting for the dot. Having a VERY tall front sight installed helps, as it draws your eye to the correct height as you lift the gun.
Good luck, and have fun. Big revolvers are sweet!
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