So if it came down to only choosing a few powders in regards to rifles, I would have to go H1000, H4350 and 8208XBR. H1000 could handle most larger cartridges and my preferred bullet choices for those calibers which is long, heavy for caliber. The H4350 would cover all the Creedmoor variants and other mid size cartridges. I choose 8208XBR for smaller cartridges. IT gives me insanely low extreme spreads in 6 ARC. This is assuming all three powers are readily available for the rest of my life. Crazy thing is I have 30-40 different powders in my arsenal. I use the crap out of those three though.