I don't believe it is at all.
If you have a slightly compressed powder charge….and everything as is works fine, there is a possibility that the vibration settles the powder and changes the way it behaves.
I used to load my test batches in the house, walk outside where my bench was and test, then load however many, normally around 200 rounds for a match, and verify right there and then.
When Retumbo was first released, I did the very same thing as usual and I knew that when dumping the powder from the measure that the cases were very full, well into the neck. Verifying that load at home proves all was well.
The following morning, I loaded my gear and headed to the venue for that weekends match, it was a 4 hour drive….after setting up and having everything ready to commence I proceeded to fire my sighters. First shot was excessive recoil, mush louder and when I went to open the bolt, it was locked solid, beating it with a rubber mallet did nothing. I tried to pull the barrel, as this rifle is a switch barrel, and that even wouldn't come off. Normally I would have just used my sister rifle, but I didn't take it on this trip…silly me.
It was a head scratcher. I soon realised after pulling several bullets that the powder had settled A LOT! So I started experimenting with how the powder was dumped from the measure and after several attempts found that pouring the powder into a funnel at an angle would cause the powder to 'swirl' into the case allowing it to pack down better. With a reduced load from that initial load, I was able to cause a stiff bolt just by the way the powder was put into the case.
This is why I tell everyone that packing scheme of the powder is just as important as the powder you use itself.
This also why changing the compression of certain bulky powders and leaving an air gap is a bad idea.
Cheers.