I've had some epic prairie dog and whistle pig hunts over the decades, and one rifle is never the answer as even heavy barrels can become really hot with lots of shooting. Indeed, I've had trips where 3 or even 4 rifles were needed to let things cool down. As such, multiple chamberings made sense. My typical outing would mean bringing a a 22LR or 22mag, .223 and a 22-250. If I were starting from scratch, I'd probably have the 22-250 using a faster twist to shoot the heavier bullets for longer shots in the ever blowing winds of the west. As it was, I used 55g BTs in both the 223 and 22-250 as I learned early on the extra wind drift associated with lighter bullets. I've often wondered how accurately tracking scopes might have improved our hit ratio. We'd sight in the 223 for 200yds and the 22-250 for 300. Wind and elevation holds were all seat of the pants.... Lots of shooting fun, but not particularly efficient. I remember days of expending 1000+ rounds in a day, multiple cleaning breaks, and coming home with blisters
