Best All Around Caliber for Whitetail and Mule Deer?

[RB II]

Something in .284 is my suggestion. 7 mag on up with 8.5 or faster twist rate. Shoot anything from 150 gr to 175-180 grain bullets at decent velocity.
Covers pretty much the whole spectrum IMO.

 

[Dirtybird552]

Another vote for .308

 

[Gristle]

I'm gonna toss in my vote for a 280

 

[AussieWriter]

Choices are endless.
If Weatherby is a thought.
257 and 6.5/300.

And the 270 and 7mm Weatherby's. Too often forgotten or omitted, but seldom beat.