ShootnMatt- Looks like you're barking up the right tree so far. I'd go 8 twist, no reason not to even if you're shooting 40's-55's. Then if you ever had the want to shoot the heavies you sure could.
I love the 22/250, as well the Swift, I also had both of those in AI versions. I did it for the lack of trimming not for any speed gains. Only issue I've had is that the feeding isn't as smooth as the non AI cases (note I didn't say that it won't feed, just that it isn't as smooth...). The other issue I had with the Swift was the case necks flowing and I needed to trim the inside necks. Personally I'd do a Swift AI but I wouldn't do the non AI just for that reason. Life is short and I absolutely dislike trimming cases being it for length or inside.
I haven't done a CM as of yet, I have a Lilja 3 grove 8 twist on a order for my main rifle. It'll be rebarreled sometime in 2025 so I have some time to sort out which way I wish to go. When push comes to shove I'll probably go 22/250 or Swift AI.
Brass has been a bit of a challenge for both the 22/250 and the Swift but as of late I've been able to find it. Whatever way you go I'd buy 10 bags to go with the new barrel and know that you're set for the life of the barrel.
I used to beat on the yotes pretty hard (40-50 dogs a year), I don't have much against them anymore but the grandkids seem to have some interest so we may well get into the swing of things again
Best of luck to ya, I truly calling any critter that I can make go from point A to close to me.