Absolutely, there's no doubt. Hit being the operative word. I went through this argument in the other thread too, the issue is in order to have a high hit probability you have to practice, a lot. If you practice with that big bore a lot, then by all means, carry it.
I would venture a guess that 90-95% of people who buy a big bore revolver for bear defense do not practice with them remotely enough to hit a charging bear with a stopping shot
I once had the opportunity to fire a freedom arms model 83 in 454 casull and it was the most violently unpleasant gun I've ever shot. Thats not even mentioning the added mechanics of running wheelguns
I'll stick to a striker fired 10mm that I can practice with comfortably and draw-point-shoot relying on instinct and actually hit a bear if heaven forbid i did ever end up in the situation