As it seems there's still a little confusion, I'm not talking about defensive use, as most places I'm likely to hunt don't have anything that needs a serious revolver. I was more thinking about shots of opportunity at close range. For example, trudging up a gully with your rifle slung, and you bust an animal at 60 yds.
Sounds like the consensus is that a 44 mag is sufficient for elk at "archery ranges", so either my 454 or 475 should be good. Just crunched a few numbers, comparing my 4-5/8" 44 mag Blackhawk, which runs a 240 XTP at about 1300 fps (my handholds).
At 20 yds, the 44 has 1250 fps and 840 ftlbs.
475LB with 400 gr pill has velocity match at 35 yds, energy match at 200 yds!
454C with 300 gr pill has velocity match at 125 yds, energy match at 190 yds!
Obviously, I wouldn't take a shot on live game with an iron sighted wheel gun past about 80-90 yds, but I might investigate putting a red dot on my FA 454. Think it would push my "ethical range" out to 100-120 yds. Is a quality micro red dot gonna stand up to 454 recoil though?