When I was shooting the 169's I shot them out of a 28 Nosler at 3260fps. I had them up to 3330 at one point, but my throat was eroding extremely fast causing a loss in velocity. I killed 2 buck and bull with the 169's last year. I would not hesitate to use them within their 1800fps impact limitations.
I only got away from them this year because I wanted to start shooting truly long range, and the low BC really is a factor in that. But 6-800 yards with the right cartridge pushing them fast enough, they're legit bullets.