Just so happens I learned that the hard way a couple weeks ago. I was out Mule Deer hunting with the .308 AR10 I built loaded with Hornady Superformance 150gr SST factory ammo when a 6x6 Elk presented itself. At 300yds all the shoulder shot did was make the poor fella limp. The 250yd hit through his spine ½ way between shoulder & head fortunately dropped him like a sack of potatoes. Had I had my 6.5x55 with the 140gr Berger VLD Hunter round I've developed, I have little doubt his heart would've been pulverized with the 1st shot.