Just and example but when running Mt lion I started out carrying large heavy hitters, 44mags and 357's, we found that nearly nearly all lion came down alive and would usually go for 50+ yrds, some farther with a good chest shot and they can get to some bad spots.
We then started packing 22 rf or mag and shooting them through the heart or lungs and we found they just don't flip out and go into drama mode and they fall out of the tree dead in under a minute. Almost always finding the bullets under the hide.
I think this also happens when shooting at longer ranges on game, they don't have a clue and they don't tence up, I've shot a few deer with a 22rf and they might spook alittle but then they go back to what they were doing then the lights just shut of and they fall over, fast, clean and no disterbance in the area.
More than one way to skin a cat gun)