No matter what bullet is used I'm sure there are potentials for failure. I can't think of a single bullet that has a guaranteed result in finding the animal. Shot placement is everything and being within your comfort zone. For me, being a PRS competitor and having the equipment I have, custom-built rifle, kestrel, high-end optic, etc, it would not bother me a bit to take a 1000 yard shot with my PRC on an antelope. Even farther for a bigger animal. Its what I do almost every weekend and half the time through the week. I am comfortable in my shooting and know my abilities.
Had a guy a the range the other day sighting in his rifle. Basic Remington 700 7Mag. I struck up a conversation about that being slightly overkill for the upcoming deer season here in MO. He says no, Im going on an elk hunt out in CO later in the year. He was saying that he's 2" high at 100 so he should be dead on at 200 and about 3" low at 300. I asked where he got this info and he said it's on the back of the box of ammo. I asked if he's verified any of this other than shooting 100 or 200 yards. He says no. This is a recipe for a lost animal. His plan is to just "estimate" his holdover or the Ol' Kentucky windage and hope for the best. This is not *Rule 1 Violation*al hunting in my opinion. I offered to help him verify his data through one of the numerous ballistic apps I have and he politely declined. Oh well!.
Sorry for the long rant but there's not a bullet out there that will guarantee you find the animal. There's another thread I started reading about larger calibers making up for poor shot placement. There's some interesting reading on the opinions on that subject!