I've lived in Alaska the past 45 years and hunted moose since childhood, have taken moose with an assortment of cartridges and was present in hundreds of hunts with hunters using various other cartridges
While we like to remember the good times, and successful outcomes give us good memories, sometimes the worst scenarios are remembered most wether we want to or not, those disastrous hunts always involved lesser cartridges, nothing I hate more than crawling through the wilderness in the darkness searching for a wounded animal, I'd much rather be at the campfire sipping whiskey and toasting my feet near the flames
Moose aren't hard to kill but for such a large animal, "shot placement" and timing almost never seem to line up properly, regardless of how well most seem to think they have trained themselves, and this is where the smaller cartridges fail
Believe me, when a new moose hunter sees a huge body with massive antlers step out from cover, your knees and hands will shake, all thoughts of shot placement and "I'm a sniper" will vanish, and this is where the bigger cartridges are supreme, line up on the shoulder and hammer him hard
This past September I shot my 31st bull moose at 250 yards with a 338 Edge, one knee down on the ground and elbow on the other knee, I lined up the crosshairs dead on the shoulder and the 265 gr CEB MTH bullet smashed the bull to the ground, never made a single step ...
I wasn't overly concerned about "shot placement", staying off the shoulder bones, heart or lung shot, feed it between the ribs, spine or neck shot etc ....
The simplicity of point and aim center mass and send with 100% confidence of favorable results cannot be overstated or argued away with "too much gun" and other such nonsense, now "not enough gun" ... THAT will create more problems than you have time to deal with
Power... it's a wonderful thing