The biggest issue I have found with factory ammo is not necessarily the short range accuracy/precision which can many times best a handload, but the velocity-ES. This is not that much of an issue a short/mid ranges but can make a material difference depending on target(game) size at the longer ranges. Quite frequently, ES is a function of a specific ammo/barrel/chamber combination and the load needs to be tailored to achieve the best results. I often use factory ammo in my 223 and 22-250 for predator hunting to 400/500 yards but found I need to use precision handloads for my long range shooting for best results.