You won't like the weight or the recoil. Not having hefted a 460 versus the 500, I can say the 500 is cumbersome while the 44 is large but still handleable (I think thats a word...lol)
You can't hip holster a 500 (not sure about the 460) but my 44 (with iron sights instead of the scope) is easy to wear in a DeSantis.
Like I said in a previous post, I'd have a .41 (I had one years ago and took a bunch of deer with it but sold it and never got another. You can one hand a .41 for a snap shot. You can't a 44 and I'm pretty sure a 460 is a 2 hander like the 500.
Maybe Clint Eastwood can one hand a 44 but I can't.