This is just my OPINION , as I have not had to stop a charging bear , or any other animal that is capable and intent on killing me .
Unless you get a shot into the brain , spinal cord/central nervous system where they attach to the brain , or destroy the spinal column at the front shoulder junction , you will not be able to drop that animal in it's tracks .
Starting at .338" diameter , and larger calibers , shooting heavy-for-caliber Partitions , A-Frames , solids , or .45-70's shooting heavy hard-cast projectiles , even Elephant rifles , or very large-caliber pistols , you will still have to hit those spots to stop them .
That being said , those heavy , deep-penetrating projectiles that have the mass and structure , just might intersect the spine at a different location , after having missed your primary aiming point .
DMP25-06