I think the 375's are the sweet spot for power / accuracy / extreme long range killing power, but still being "reasonable" as far as muzzle blast, weight, etc.
I am currently building a 9.5 x 70 (AKA 375 Lapua improved) on a Defiance AnTi action, 5 round DBM, 26 in Bartlien, carbon fiber M40 stock. Rifle will weigh 10.5 lbs. with a NF scope on it. I have an exact one in 338 Lapua Improved (built on a Defiance ultralight)
Rifle is throated for the 350 Cutting Edge MTH, but will also test Steve's Hammers and the Barnes.