I used my 28nosler 195 Bergers to kill 4x4 Muley at 300yds,dropped in his tracks. Same hunt killed a 6x6 bull 986 yards just behind the shoulder, turned 180 degrees and I put a second followup shot on him with out even thinking, due to it being last half hour before dark, thick oak brush and last day of season. I wanted to anchor him. He folded, massive damage to vitals and bullet exited the opposite side,the other bullet I found just under the skin on the opposite shoulder. Shot a Cow same hunt 748yds just behind the shoulder, legs buckled and dropped strait to the ground, massive vital damage and exited the opposite side. My buddy used my gun to kill his cow at 350yds same DRT with a exit hole I could put my fist in. In all animals I could not believe the internal damage and found bullet fragments radiating out from the entrance hole some as far as 20". One thing I would recommend if you are shooting closer ranges make sure to shoot behind the shoulder not center of the shoulder.