I would 2nd this. If you twist the .25-06 to 7.5 or 8 and it doesn't like the Berger 133 or they go "extinct," then what? Nothing else you can fund will likely survive or shoot well due to the fast twist/velocity combination. 6.5 long action makes sense except for brass availability or the difficulty in forming it and/or finding dies and time to do so. 6.5x284 is readily available, but it can be a chore to find bottom metal/action lengths ideal for handling the in-between case size. If you can beat this issue out first, then it is about as perfect as you can get for deer and mule deer. Good for elk, too. But the 8 or 8.5 twist .270 will handle all of your 140 - 175gr pills well, there's plenty of brass and bullets, it's a better choice for the large species, and factory ammo is handy, which it isn't for the other choices. The ONLY issue I've run into in planning to build one is finding a barrel available twisted accordingly without a several-month wait. The barrel makers are behind the times or don't want to change their programming, so anything you find ready to ship will be 1:10. Same with the .25cal except there are a few offering 7.5 twists to buy now, but like only 1 with an 8 twist handy. Everything is still a 1:10 on the shelves. Not sure why the barrel makers are lagging behind the rest of the industry here, but they are the rate-limiting step of the process for sure when it comes to .270 and .25 bores. You won't go wrong with any of your choices, but you need to see what parts and components are available for each to fully decide. An 8 twist 6.5x284 in standard long action MIGHT be your path of least resistance to getting bullets on paper the fastest and easiest.