I grew up over 60 years ago using a 32. Winchester Special - model 94 LEVER ACTION - and the 170 grain Silver Tips - at only 2,200 fps or so - really dropped deer. If there are somewhat equal choices - always like a heavier bullet for the shock factor delivered. So for moi - I would go with the .270 - which was also very popular back then - but my dad had the trusty ole 30.06 Sporterized Springfield 1903 - if we needed longer range shots than in the Oregon Timber - usually not more than 100 yards.