Baydog,
Typical shots for our coues wt are well over 200 yds. Longest shot I have done with the Roy is 580 yds on an antelope and 525 on a coues deer. I set my rifle up so I have don't have to do any compensation till I am past 500 yds. See chart at end of post.
RL-25 or RL-33 will yield more velocity with the 110 accubond or 115 Berger VLD than H-1000, Retumbo or even RL-22.
I currently am using RL-33 with a moly coated 115 VLD in a 27.5" 3 groove Lilja. The velocity is the fastest I have ever experienced with the 257 weatherby and I hesitate to mention it. The velocity is a stunning 3680 fps with 83 grains of powder. This was measured with a magneto speed chronograph and verified at the Tucson Rifle Club's silhouette range. Trajectory/comeups matched perfectly for the 300 M javelina and the 500 M ram.
I was one of the first to work with RL-33 was when it first came out. I posted results with several chamberings here. I had to do some testing to develop the load data as Alliant doesn't mention this powder with the 257 Weatherby, still doesn't. RL-33 is slower than RL-25 so I started the mid range loads of RL-25 to begin with RL-33 and worked up from there.
When we used RL-25 we used 74 to 75 grains which is a bit over what Nosler's suggestion of 72 gr for their max load data with the 115 ballistic tip. The ballistic tip has more bearing surface than the 115 VLD and isn't coated. The velocities with RL-25 were running a bit over than 3600 fps with all five rifles . This combination of custom reamer, longer 3 groove barrel, VLD, and moly coating has shown itself to work with six lilja 3 groove barrels. The sixth rifle is using H-1000 and velocity is a bit over 3300 fps.
Flat? You bet. We shoot our deer at 4000-5000 ft. Here is trajectory for my rifle at 4000 ft
100 2.8
150 4.0
200 4.4
250 4.1
300 2.9
350 1.0
400 -1.9
450 -5.6
500 -10.4
Wind drift at 500 yd in a 10 mph crosswind is 8.7"
If I were to zero the rifle for 100 yds here is how flat it would be:
100 -0.0
150 -0.3
200 -1.3
250 -3.3
300 -6.1
350 -9.9
You asked......