I have tried a lot of powders in the 25-06 over the past 25 or so years but none of the newer IMR ones. IMR or Accurate 4350 or H4831 or the SC version is hard to beat. Yes you may get just a little more velocity out of some but the accuracy is not there. I have killed a few hundred white tail deer (did crop damage control for 15 years) out to a little over 500 yards with 117 Sierra Pro Hunter with 49 grs of either IMR or AA 4350 (they shoot the same in my rifle), Rem case, CCI 250 and average 3000 fps and 1/3 MOA out of my 26" #6 SS Shilen barrel Rem 700. 99% of the time it is BANG FLOP on deer. I have read on other sites where people have had good results with the 115 VLD using Retumbo. I have never tried this bullet. I have always been and "if it ain't broke don't try to fix it" kind of guy and I have a few hundred 117 Pro Hunters in my stash.