I have a v1 Weatherby Vanguard 243 in 1:10 twist. For deer, I use the 90G Nosler Accubond when I can find it, the 95 BT when the AB is not an option. Both are effective. But the Nosler 55G BT shoots great in this rifle. In fact, it's about 4" high at 100 yards where the 90 & 95 are at 1.5" high. The 55G is going about 3800 fps and is, no doubt, a barrel burner. But it's flat at 400 yards, and retains enough energy (maybe 600 ft/lb) to take other game. I am not good enough at that range to comfortably take a shot at a deer. And it's not going to drop a deer without a masterful or lucky shot. I might do it on a hog, but why? A neck shot would bring it down, I guess. But what am I doing? I guess I'm saying that a 1:10 twist is the wrong barrel for long shots in 243.