The 25-06 is a better solution for longer ranges and will handle Mule Deer. The 100 grain 243 does not handle the wind as well. I have been using the 25-06 and the 117 grain GameKing with 52 grains of H4381SC for years out past 500 yards and have really had good luck. I have a 240 Cobra that is equivalent to the 243 and it works well on white tails, but the wind is an issue in Wyoming.