25-06 all the way for me. If your worried about the hides or saving powder then use something like a 204, 22-250 or one of other 22 calibers. You can run ballistic programs all day long, compare powder capacity, recoil and what ever else, but at the end of the day its going to be you hit or missed your target. If a 243 gives you that confidence and results time after time, go for it. For me and a few other 25 caliber crazy's, the fast hard hitting power of the 25-06 is magic.