FWIW I run 53 vmax out of my 1:12 twist 223 with an Sg of 1.02 with great results. It completely falls on its face at transonic (very erratic vertical), but before that its sub 1/2 moa all day out to 600 in calm conditions.
Run some numbers on your typical 1:12-1:14 22 cal centerfires. Absolute garbage for Sg's (in some cases below 1), but many people have great results despite this.
Obviously if you have a choice in the matter, then of course, choose a twist rate to give you 1.5+ Sg for optimum bc and transonic/subsonic transition results.
What i'm saying is just because the calculator shows a less than ideal number please don't be a afraid to try it out.
p.s. my altitude is only 500 feet asl.