When a guy could apply for a hunting permit and gun permit to hunt in a particular state in Mexico, we hunted there at least 8 weeks out of the year for predators, that ended around 1991 or so when their new president passed a law that Gringos had to have a "guide" with them at all times.
The predator hunting was incredible to say the least with weekend hunts ranging from 13-56 tails taken. We did a lot of bullet testing. Some bullets are just ok, while others really shine on energy dump, putting the animal down in it's tracks.
Bullet choice really matters when it comes to hunting vs target.
I will never forget one of my first really bad bullet/velocity combo's. I was using a Weems Wild call, duo tone hand call. A big coyote came in and stood broadside to me around 150 yards, he had caught a whiff of something he did not like, stopped in his tracks. I was shooting a custom 22/250 with Sierra 60g HP loaded to 3450 fps. I hit him solid behind the front leg in the lungs, he trotted off without a care in the world at bullet impact. He stopped again on a broadside shot around 200 or so, and I hit him again, lung shot. Again, he trotted off. I figured that I had lost him, but he showed up again around 300 yards licking blood running out of the entrance holes, I made the decision that I needed to shoot him through the shoulders, and he collapsed at the shot.
When we retrieved him, he had two holes through the lungs about 2" apart, but they had not broken the diaphragm. The shot through the shoulders killed him. I carried a Buck Lite knife on my belt and immediately just unzipped the coyote right down the middle of the spine under the skin, and peeled the hide back. The bullets looked like they had never expanded.
So, on the rest of the hunt that weekend, I knew to shoulder-shoot the animal or head if possible.
I gave the rest of those 60g Sierra to a friend who was shooting them in a 22 Cheetah at 4000 fps.
My 60g Problems ended when I switched to a 60g Berger which is just an incredible bullet for coyotes in 22/250-22/250 AI speeds, blowing a teacup size hole on the off side. The 60g Berger proved to be a bullet worth building a rifle around, 12T zero to .020 Freebore.