Over the years, we have shot alot of big game with various .22 centerfires ..Starting with the .22 Hornet up though the .22 Cheetah..In those days we often hunted several states each fall, and those rifles were legal there..While we never experienced a problem..I do wonder about some clown taking an AR with a 30 round mag. and starting to blast at a herd of antelope..Not that AR users are all bad, I have one myself and enjoy it..BUT when I see the damage and things destroyed by folks at the local range, I wonder about many of our shooters..Of course not all the damage was done with AR's or similar weapons..But the group that scares me most there are the beginners with a semi of any kind and a big box of ammo...What could be done to a running herd of antelope is kind of scary..
On the other hand, one of my very best friends, now hunting in a better place, told me when the .222 first hit the market, he bought a new 722..Over the years he killed 11 mulie bucks..Mostly with factory ammo and open sights!!! Again much of the success comes back to the person behind the rifle, some are pretty inexperienced...