I got my best velocity and accuracy with 4895 and 50 grain bullets-3,800 fps . H380 does not work with my rifle 'cause i get pressure signs quickly .I bought an unfired 22-250 from an estate almost a year ago. Thought I would load some MKs to go to our antelope unit to kill any coyotes we find to increase the upcoming antelope birth rate. I've been using one of my .257 Wby's, but want to save a little on components and wear. I received a box of 500 52gr MKs with the rifle and since I have them I'll shoot them. I bought 200 Nosler cases just need info on powder experience for this bullet. Thanks in advance.