Depending on your expected ranges and annual round volume, the choice can vary. If you use a 223 with a 9" or faster twist, the 65 to 75gr bullets work wonders at the longer ranges, but if you expect the majority of your shots to be 300yds or under, the 50-55's are very effective. If you plan to occasionally shoot larger volumes of rounds for practice or other pests, the 223 keeps things cooler and cheaper. Here in the West, 22-250, 22-250 AI are my go to for longer range yotes, and with 1/9 and 1/8 twist barrels, 75/80 gr bullets reach way out, buck the wind well and hammer yotes hard.
I have a couple of 20" and 24" heavy barreled 1/8 twist 223/5.56 AR's I shoot the 68 to 75gr bullet in, and the fast follow up shots on multiple sprinting sage brush yotes does have advantages.
If your state allows, a 22-250 loaded with Barnes X bullets makes a decent deer load to boot. I know guys in the Southern US who call yotes during their long deer seasons, and carry a few rounds of TSX's for the Whitetails that occasionally and curiously come in to investigate the yote calls.