In wyoming it's not a legal caliber. Not sure in other states.
A 22-250 will kill antelopes! My dad has hunted with one for 30+ years he started out shooting 50 grain hornady sp (cheap) bullets when he was 19 years old. He has taken white tail deer out to 500 yrds (kentucky windage) several times I also know someone that shot a bull with one ,stupid I know but they killed a bull with a 22-250 . If you plan to shoot a 22-250 you need to place the shot well , just as any caliber practice good shot placement . The biggest reason that I don't hunt with one is because if the wind blows your in trouble.So 22-250 can kill an antelope but would need to be shot under 200 yds with the right bullet and be in a state that allows you to use a small caliber. But why mess with limits just go up in caliber size.
grit - perfect.Seems a bit funny to worry a 243 is too much for coyotes and not worry the 22-250 is too small for antelope.
Both will do both jobs well. The 6mm will offer a significant advantage in wind drift and energy in factory guns. Most 22-250's are a 1 in 14 twist which would radically limit the usefulness of the 22 for big game.
I think if you really want a multi purpose tool the 243 is a hands down winner in this case. If you really want a 22-250, it'll darn sure kill antelope and deer too. Just be aware of its limits.
My suggestion for hammering turbo goats with a .22-250 Rem would be to; re-barrel to a 1-7 or 1-6.5 twist and using bullets from guys like Robert at North West Custom Projectile in a bonded 85gr to 90gr. What I did was to, re-barrel to a 1-7 twist 28" inch chambering to a .22-250 Ackley Improved; works great, good range, very, very accurate. But in the end I could've just used a .243 caliber with the same bullet weights'…, duh! I have used .22 caliber 60gr Nosler Partition bullet on deer size game from the standard .22-250 Rem and found them to work very well {Idaho} from 1-10 and 1-12 barrels. The Nosler Par 60gr bullets do not like the 1-14 twist at all. This bullet {60gr Par} or one of the heavier Barnes TSX BT 62gr'ers in .22 cal bullets would be my pick for turbo goats out of a standard .22-250's using the 1-10 or 1-12 twist.
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