I've had really good luck with the 20 grain and the 15 grain. I have never shot the 25's, actually haven't even seen any in my neck of the woods, NE Ohio. I mentioned in earlier posts about Savage tuning my old, (bought it in 2012) "pencil barrel". They used the 25 grain for accuracy testing and sent me the target with the rifle, and of course, I lost the target!! It shot a 5 round 1/2" 100-yard group at their indoor range, I'm assuming from a stationary vice?? So I guess it depends on the rifle? All you can really do is try all three, 15's, 20's, and 25's, and judge for yourself?? In both my rifles, "pencil" and bull the 15's and 20's shoot almost identical, even though their twist rates are different. I opt for the '20s because they're cheaper and easier to find. However, if trying to take down coyote I would probably look at the 25's?? But I have a custom AR in 223 Wylde that I use 223 ammo I load specifically for the task. Or my trusty Savage 112 26 inch bull 22-250 if I don't have to carry it's 25+ pounds more than 10 feet! Being in my early 70's I now have the strength of two small children! One more note, I replaced the Veridian scope on my "pencil" with an Athlon Optics Talos 3-12x40. The Veridian is a decent scope, but it got damaged when I had it off the rifle and dropped it on concrete!! ( Smooth move butterfingers!!) Any way the Athlon seems to be a notch to two above the Veridian, it tracks flawlessly and it's more compact so I guess it all worked out for the better.